Phosphorothioate oligodeoxynucleotides: What is their origin and what is unique about them?

Authors
Eckstein, F
Citation
F. Eckstein, Phosphorothioate oligodeoxynucleotides: What is their origin and what is unique about them?, ANTISENSE N, 10(2), 2000, pp. 117-121
Citations number
42
Categorie Soggetti
Molecular Biology & Genetics
Journal title
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
ISSN journal
10872906 → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
117 - 121
Database
ISI
SICI code
1087-2906(200004)10:2<117:POWITO>2.0.ZU;2-X
Abstract
The development of nucleoside phosphorothioates is described in its histori cal context. Examples of the interaction of phosphorothioate groups, presen t either in oligodeoxynucleotides or in DNA, with nucleases are presented. The structural features responsible for the resistance of the phosphorothio ates toward degradation by nucleases are discussed, as are the possible rea sons for the high-affinity interaction of phosphorothioate oligodeoxynucleo tides with certain proteins.