An analysis of the kinetics of unstable enzymatic systems using MAPLE

In this paper, we presented a general kinetic analysis of the reversible en zymatic system for the case in which the substrate, the enzyme-substrate co mplex and the product are all unstable. Using computer algebra technique, w e solve the system of ordinary differential equations symbolically under th e assumption [E] >> [S]. Since this condition satisfied inside the cells, i t can be more relevant to physiological problems. Then using numerical valu es, simulation progress curves for the concentration of all species are obt ained. (C) 2000 Elsevier Science Inc. All rights reserved.