Molecular cloning and characterization of a novel human gene (NESCA) whichencodes a putative adapter protein containing SH3

Authors
Matsuda, S Miyazaki, K Ichigotani, Y Kurata, H Takenouchi, Y Yamamoto, T Nimura, Y Irimura, T Nakatsugawa, S Hamaguchi, M
Citation
S. Matsuda et al., Molecular cloning and characterization of a novel human gene (NESCA) whichencodes a putative adapter protein containing SH3, BBA-GENE ST, 1491(1-3), 2000, pp. 321-326
Citations number
20
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1491
Issue
1-3
Year of publication
2000
Pages
321 - 326
Database
ISI
SICI code
0167-4781(20000425)1491:1-3<321:MCACOA>2.0.ZU;2-F
Abstract
A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1990 bp and has a pr edicted open reading frame encoding 433 amino acids. It possesses an Src ho mology 3 (SH3) motif, a leucine zipper motif and no catalytic domain, sugge sting that it seems to be an adapter protein. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the g ene to human chromosome 1q21-22. (C) 2000 Elsevier Science B.V. All rights reserved.