Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease

Authors
Takahashi, M Iseki, E Kosaka, K
Citation
M. Takahashi et al., Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease, BRAIN RES, 862(1-2), 2000, pp. 253-256
Citations number
16
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
862
Issue
1-2
Year of publication
2000
Pages
253 - 256
Database
ISI
SICI code
0006-8993(20000417)862:1-2<253:CK5(AW>2.0.ZU;2-J
Abstract
We investigated the cyclin-dependent kinase (Cdk) 5 distribution pattern in diffuse Lewy body disease brains using immunohistochemistry. Cdk5 immunore activity was detected in both brainstem-type Lewy bodies (LBs) and cortical LBs. The number of Cdk5-positive LBs was less than that of ubiquitin- or a lpha-synuclein-positive LBs, and more than that of phosphorylated neurofila ment-positive LBs. Immunoelectron microscopy revealed Cdk5-immunolabeled gr anulo-filamentous components in LBs and LB-related neurites. These data sug gest that Cdk5 may be associated with LB formation. (C) 2000 Elsevier Scien ce B.V. All rights reserved.