The toxic effects of a gas depend on the time of exposure, concentration an
d its chemical nature. Pressurized liquids and gases exert an additional co
ld thermal injury and this may complicate the clinical picture. A patient w
ho had an accidental exposure to liquid ammonia over a prolonged period, ma
nifesting in cutaneous, respiratory and ocular damage in addition to a seve
re cold thermal injury (Frostbite) with a fatal outcome is presented. The p
atient had flaccid quadriparesis and episodes of bradycardia, which has not
been reported previously. These manifestations raise the possibility of th
e systemic toxicity in patients with prolonged exposure to ammonia. (C) 200
0 Elsevier Science Ltd and ISBI. All rights reserved.