Hypercalcemia due to talc granulomatosis

Pulmonary disease due to talc, a group of hydrous magnesium silicates, is a lmost exclusively encountered after occupational exposure. One form of this rare disorder is tale granulomatosis. In varying degrees, hypercalcemia is typical of granulomatous disease hut has not yet been reported in talcosis , We report the case of a former mold maker who presented with hypercalcemi a. Laboratory findings indicated extra-renal I-alpha-hydroxylation of 25-hy droxyvitamin D. Pulmonary infiltrates prompted a lung biopsy that disclosed talc granulomatosis, We suggest that talc granulomatosis should be added t o the list of granulomatosis disorders capable of causing hypercalcemia due to increased extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D.