Hemofiltration in sepsis: where do we go from here?

Hemofiltration as an adjunct to therapy for sepsis is now 10 years old. Des pite early successes and significant theoretical advantages, the treatment remains experimental. Although feasibility has been established, efficacy h as proved to be much more difficult. Clinical as well as technical difficul ties remain important considerations to future studies. These issues are di scussed and the brief history of hemofiltration in sepsis is reviewed.