MULTIFOCAL EOSINOPHILIC GRANULOMA WITH SEQUENTIAL PERIODONTITIS-LIKE LESIONS

Eosinophilic granuloma (EG) is the localized and mildest form of the t riad commonly known as Langerhans cell histiocytosis. This report desc ribes a case manifesting itself as a peridontal problem with the local ized osseous lesions in jawbones which Nas first diagnosed as early-on set periodontitis. Later on, the diagnosis of EG was established, rely ing on histopathological and immunohistochemical evaluations. Immunohi stochemical findings confirm that a minor component of cell aggregates is phenotypically related to Langerhans cells among the sheet-like ac cumulations of histiocytes and eosinophils. The aetiology of the disea se remains largely unknown, Although surgical curettage of lesions is usually effective in treatment of EG of bone, corticosteroids might be used as an adjunctive. This multifocal case of EG stresses the import ance of clinical follow-up examinations, since the sequential lesions appear with irregular intervals, and this may cause diagnostic problem s as well as a delay in starting the treatment regimen.