C. Dean et Jl. Seagard, MAPPING OF CAROTID BARORECEPTOR SUBTYPE PROJECTIONS TO THE NUCLEUS-TRACTUS-SOLITARIUS USING C-FOS IMMUNOHISTOCHEMISTRY, Brain research, 758(1-2), 1997, pp. 201-208
This study has combined physiological pressure stimulation of carotid
baroreceptors via a vascularly isolated carotid sinus and anodal block
of baroreceptor afferent fibers in the carotid sinus nerve to examine
the medullary projections of type I vs. type II (large A- vs. small A
- and C-fiber afferent) baroreceptors. The control distribution of cel
ls in the nucleus tractus solitarius expressing c-fos in response to p
hysiological activation of carotid baroreceptors in the isolated sinus
was compared to that during anodal block of large A-fibers in the car
otid sinus nerve. Carotid baroreceptor stimulation primarily activated
neurons in the ipsilateral commissural and medial subnuclei of the ca
udal nucleus tractus solitarius and the dorsolateral, dorsomedial and
medial subnuclei in the intermediate and rostral levels of the nucleus
tractus solitarius. Elimination of large A-fiber carotid baroreceptor
afferents, during similar carotid baroreceptor stimulation resulted i
n a decrease in the number of cells expressing c-fos in the dorsomedia
l subnucleus of the rostral nucleus tractus solitarius. These data ind
icate that projections of larger A-fiber (type I) carotid baroreceptor
s are localized primarily to the rostral dorsomedial subnucleus, while
those of smaller A- and C-fiber baroreceptors are more widely distrib
uted to the commissural, medial and dorsal subnuclei of the nucleus tr
actus solitarius.