The role of cytotoxic necrotizing factor-1 in colonization and tissue injury in a murine model of urinary tract infection

Authors
Johnson, DE Drachenberg, C Lockatell, CV Island, MD Warren, JW Donnenberg, MS
Citation
De. Johnson et al., The role of cytotoxic necrotizing factor-1 in colonization and tissue injury in a murine model of urinary tract infection, FEMS IM MED, 28(1), 2000, pp. 37-41
Citations number
22
Categorie Soggetti
Immunology
Journal title
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
ISSN journal
09288244 → ACNP
Volume
28
Issue
1
Year of publication
2000
Pages
37 - 41
Database
ISI
SICI code
0928-8244(200005)28:1<37:TROCNF>2.0.ZU;2-C
Abstract
Cytotoxic necrotizing factor-1 (CNF1) is commonly found in Escherichia coli isolates from patients with urinary tract infection (UTI). To determine wh ether CNF1 is an important UTI virulence factor we compared the ability of a clinical E. coli UTI isolate and a CNF1-negative mutant of that isolate t o colonize and induce histological changes in the urinary tract in a murine model of ascending UTI. We found no evidence that the mutant strain was at tenuated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.