17-ALPHA-DIHYDROEQUILENIN INCREASES HIPPOCAMPAL DENDRITIC SPINE DENSITY OF OVARIECTOMIZED RATS

Authors
WASHBURN SA LEWIS CE JOHNSON JE VOYTKO ML SHIVELY CA
Citation
Sa. Washburn et al., 17-ALPHA-DIHYDROEQUILENIN INCREASES HIPPOCAMPAL DENDRITIC SPINE DENSITY OF OVARIECTOMIZED RATS, Brain research, 758(1-2), 1997, pp. 241-244
Citations number
12
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
758
Issue
1-2
Year of publication
1997
Pages
241 - 244
Database
ISI
SICI code
0006-8993(1997)758:1-2<241:1IHDSD>2.0.ZU;2-Z
Abstract
The effects of estradiol and 17 alpha-dihydroequilenin on the apical d endrite spine density of pyramidal cells of the CA1 region of rat hipp ocampus were compared. 17 alpha-Dihydroequilenin was as effective as e stradiol in increasing spine densities relative to controls. 17 alpha- Dihydroequilenin is not uterotrophic like estradiol but does have bene ficial effects on the cardiovascular system, suggesting that it may be an effective single-agent hormone replacement therapy to treat menopa usal symptoms and reduce chronic disease risk in menopausal women.