Mk. Srivastava et Rb. Raizada, A limited three-generation reproduction study on hexachlorocyclohexane (HCH) in rats, FOOD CHEM T, 38(2-3), 2000, pp. 195-201
Dietary feeding of technical hexachlorocyclohexane (HCH) at 125 and 250 ppm
to rats have not shown any adverse effects on reproductive function and we
re comparable to control animals in a three-generation study. There were no
major malformations, while some minor variants found were not compound or
dose related. Despite some mild toxicological effects in rats of the P-0 ge
neration, the litters of F-1B, F-2B and F-3B generations were devoid of any
morphological or teratological changes. The presence of HCH residues in vi
tal tissues of F-3B pups have indicated transmigration of HCH in preceding
generations but not to an extent that produced adverse effects. (C) 2000 El
sevier Science Ltd. All rights reserved.