Prognostic factors should always be taken into consideration before plannin
g treatment. As reported in the literature, and also in our experience, the
extent of intestinal wall invasion and the lymph node status must be consi
dered the most important prognostic factors.
In the present paper the data from literature are reported and the impact o
f biologic factors is analyzed. We are convinced that in the future the bio
logical factors of the tumor as well as of the patient should be considered
in planning treatment.