A comparative study of immunochemical fecal tests for detection of colorectal adenomatous polyps

Background/Aims: This study was conducted to assess the diagnostic validity of new different immunochemical fecal occult blood tests for colorectal ad enomatous polyps, including reversed passive hemagglutination test (Immudia -HemSp), combination monoclonal antibody guaiac test (Monohaem), latex aggl utination inhibition test (Iatro Hemcheck), and latex agglutination tests ( LA Hemochaser, OC-Hemodia). Methodology: Two hundred and fifty patients with colorectal adenomatous pol yps 1.0cm or larger in diameter and the same number of healthy controls ser ved as subjects for the study. Each subject received a set of 5 immunochemi cal tests within 3 consecutive days, and sensitivities and specificities of these tests were evaluated. Results: Mean sensitivity and specificity in a set of 5 immunochemical test s were 47.6% and 95.8%, respectively. Sensitivities and specificities of 5 different immunochemical tests were calculated as 47.6% and 96.8% for Immud ia-Hem Sp, 46.8% and 95.2% for Monohem, 46.4% and 95.2% for Iatro Hemchek, 48.0% and 96.4% for LA Hemochaser, and 49.2% and 95.6% for OC-Hemodia, resp ectively, showing no significant difference in sensitivity and specificity among the 5 tests. Conclusions: These findings suggest that there is no difference in the degr ee of accuracy for colorectal adenomatous polyps among several types of imm unochemical fecal occult blood test.