CEREBRAL INVOLVEMENT IN 2 PATIENTS WITH WEGENERS-GRANULOMATOSIS

Two cases of cerebral involvement in Wegener's granulomatosis (WG) are described. The course of the disease in both patients was characteriz ed by sudden onset and fatal outcome, despite maximum immunosuppressiv e therapy. Cerebral involvement is a rare complication of WG. Over the past two decades, only a small number of case-reports appeared of pat ients with WG who showed this complication. Since the era of cyclophos phamide therapy, it is commonly assumed that cerebral involvement in W G has no influence on patient survival. However, the two patients desc ribed here both died shortly after the occurrence of central neurologi cal symptoms.