Linkage of recessive Robinow syndrome to a 4 cM interval on chromosome 9q22

Autosomal recessive Robinow syndrome is a form of mesomelic dwarfism with m ultiple rib and vertebral anomalies. Using autozygosity mapping we have ide ntified a genetic locus (RBNW1) for this syndrome at chromosome 9q22 in sev en consanguineous families from Oman. Our results indicate that the gene li es within a 4 cM region between markers D9S1836 and D9S1803 (maximum multip oint LOD score 12.3). In addition, we have analysed two non-Omani families with autosomal recessive Robinow and found no genetic heterogeneity.