The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

Authors
Dekkers, PEP ten Hove, T Lauw, FN Koene, HR Lumley, P van Deventer, SJH van der Poll, T
Citation
Pep. Dekkers et al., The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans, INFEC IMMUN, 68(5), 2000, pp. 3036-3039
Citations number
19
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
5
Year of publication
2000
Pages
3036 - 3039
Database
ISI
SICI code
0019-9567(200005)68:5<3036:TMIGIE>2.0.ZU;2-W
Abstract
Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inh ibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circ ulation after intravenous endotoxin injection in healthy humans.