Cytophilic immunoglobulin responses to Plasmodium falciparum glutamate-rich protein are correlated with protection against clinical malaria in Dielmo, Senegal

The goal of this study was to analyze antibody responses to Plasmodium falc iparum glutamate-rich protein (GLURP) using clinical data and plasma sample s obtained from villagers of Dielmo, Senegal. This molecule was chosen beca use it is targeted by human antibodies which induce parasite growth inhibit ion in antibody-dependent cellular inhibition (ADCI) assays. The results sh owed a strong correlation between protection against malaria attacks and le vels of immunoglobulin G2 (IgG2) and IgG3 against GLURP(94-489) (R0) and Ig G3 against GLURP(705-1178) (R2) when corrected for the confounding effect o f age-related exposure to malaria. Thus, GLURP mag play a role in the induc tion of protective immunity against P. falciparum malaria.