Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi

Authors
Babu, S Ganley, LM Klei, TR Shultz, LD Rajan, TV
Citation
S. Babu et al., Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi, INFEC IMMUN, 68(5), 2000, pp. 3034-3035
Citations number
4
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
5
Year of publication
2000
Pages
3034 - 3035
Database
ISI
SICI code
0019-9567(200005)68:5<3034:ROGIAI>2.0.ZU;2-M
Abstract
We have investigated the roles of gamma interferon (IFN-gamma) and interleu kin-1 (IL-4) in host defense against Brugia malayi. Our data suggest that t he lack of either IFN-gamma or IL-4 prolongs the time required to achieve s terile immunity, suggesting that bath canonical type 1 and type 2 responses are involved in the clearance of infection.