Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria

Citation
P. Kern et al., Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria, INFEC IMMUN, 68(5), 2000, pp. 3061-3063
Citations number
18
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
5
Year of publication
2000
Pages
3061 - 3063
Database
ISI
SICI code
0019-9567(200005)68:5<3061:ILOSFL>2.0.ZU;2-J
Abstract
Levels of soluble Fas ligand (sFasL) in serum mere elevated in patients wit h Plasmodium falciparum malaria and showed a significant decline during dis ease course. sFasL levels that were elevated before antimalarial treatment began correlated significantly with depressed total lymphocyte and T-cell c ounts. These data suggest that Fas-induced apoptosis might play a role in m alaria-associated lymphopenia.