The effect of hemodialysis and acetate-free biofiltration on anemia

The authors monitored for a period of 12 months, anemia-, nutrition-, and f ree radical-related parameters and the rHuEPO dose required to maintain tar get hemoglobin (Hb) in 20 patients with chronic renal failure. Ten patients each were randomized for treatment by either acetate-free biofiltration (A FB) or low-flux hemodialysis (HD). At baseline, Hb levels were 102+/-2 (AFB ) vs. 98+/-2 g/L (HD) (not significant difference, NS), the rHuEPO dose was 4050+/-976 vs. 5100+/-1538 IU/week (NS). Compared with baseline and with H D, lower rHuEPO doses were required during AFB at months 8, 9, 10 and II, a nd 12 when they were 2100+/-510 (AFB) vs. 6000+/-1153 (HD), p=0.008. Prealb umin, transferrin and cholinesterase levels rose in the AFB group. Kt/V, al bumin, transferrin saturation, aluminium, bicarbonate in serum, superoxide dismutase and glutathione peroxidase in erythrocytes, and malondialdehyde a nd antioxidant capacity in plasma did not differ between the AFB and HD gro ups. In terms of anemia control, AFB using an AN69 membrane was found to be more advantageous than low-flux HD, AFB improves some nutritional paramete rs. The compared methods do not differ in their effect on lipid peroxidatio n and the antioxidant system.