The acute toxicity of two formulations of ebrotidine ethyl]amino]methy
lene]-4-bromo-benzenesulfonamide, CAS 100981-43-9, FI-3542) was studie
d in rats and mice by different routes of dosing: oral and intraperito
neal routes in rats and mice (suspension), intravenous and oral routes
in mice and intravenous route in rats (injectable solution). LD50 val
ues for the oral route were indeterminable in all cases. For the intra
peritoneal route, LD50 values were 316 mg/kg (rat) and 366 mg/kg (mous
e), and for the intravenous route LD50 values were 100 mg/kg (rat) and
107 mg/kg (mouse).