Dramatic improvements in organ transplantation have meant that a growing nu
mber of patients must take expensive immunosuppressive medications for the
rest of their lives, Currently, Medicare covers most transplantation proced
ures in the United States, but ends coverage for outpatient immunosuppressi
ve medications after 36 months. Evidence suggests that at least some patien
ts have reduced immunosuppression and their transplants fail because they c
annot afford these medication costs, In the years since the advent of effec
tive immunosuppressive therapy, the US Congress has struggled with this iss
ue, and in 1999 temporarily extended medication coverage for eligible patie
nts (based on age and disability) by 8 months, However, a more permanent so
lution is needed. We advocate that Medicare should cover the cost of all im
munosuppressive therapy for all solid organ transplant recipients who canno
t afford to pay, A number of potentially cost-effective approaches could be
taken, but, in any case, something must be done to ensure that transplants
do not fail because recipients cannot pay for immunosuppression.