Residents in the southeastern United States would hardly describe life with
the aggressive imported fire ant as peaceful coexistence. The continued sp
read of these insects has produced agricultural problems, changes in the ec
osystem, and increasing numbers of subjects with sting sequelae, including
hypersensitivity reactions, secondary infections, and rare neurologic seque
lae. Evolutionary changes have facilitated their expansion northward into V
irginia and westward into California, and increasing urbanization will like
ly permit further expansion. Recent reports of building invasion with sting
attacks inside occupied dwellings, including health care facilities, heigh
ten public health concerns. This article reviews the medically important en
tomology, clinical aspects of stings, and the current approaches to chemica
l control of fire ants. We also propose directions for future research and
treatment.