Motor area activity during mental rotation studied by time-resolved single-trial fMRI

The functional equivalence of overt movements and dynamic imagery is of fun damental importance in neuroscience. Here, we investigated the participatio n of the neocortical motor areas in a classic task of dynamic imagery, Shep ard and Metzler's mental rotation task, by time-resolved single-trial funct ional Magnetic Resonance Imaging (fMRI). The subjects performed the mental- rotation task 16 times, each time with different object pairs. Functional i mages were acquired for each pair separately, and the onset times and width s of the activation peaks in each area of interest were compared to the res ponse times. We found a bilateral involvement of the superior parietal lobu le, lateral premotor area, and supplementary motor area in all subjects; we found, furthermore, that those areas likely participate in the very act of mental rotation. We also found an activation in the left primary motor cor tex, which seemed to be associated with the right-hand button press at the end of the task period.