RECENT DEVELOPMENTS IN OVERCOMING TUMOR-CELL MULTIDRUG-RESISTANCE

The development of unspecific mechanisms of resistance remains a serio us impediment to cancer chemotherapy. The term multi-drug resistance ( MDR) is defined as resistance of cancer cells to a broad variety of st ructurally and functionally diverse chemotherapeutic drugs. On the cel lular level, several mechanisms responsible for MDR have been identifi ed. In addition, numerous approaches for overcoming tumour cell MDR ha ve been reported in the literature. This review focuses on patents pub lished in 1995 and 1996 on modulators of MDR and related approaches to therapy of multi-drug resistant rumours.