NICOTINIC ANTAGONISTS (PIPERIDINES AND QUINUCLIDINES) REDUCE THE SUSCEPTIBILITY OF EARLY SEA-URCHIN EMBRYOS TO AGENTS EVOKING CALCIUM SHOCK

Authors
BUZNIKOV GA KOIKOV LN SHMUKLER YB WHITAKER MJ
Citation
Ga. Buznikov et al., NICOTINIC ANTAGONISTS (PIPERIDINES AND QUINUCLIDINES) REDUCE THE SUSCEPTIBILITY OF EARLY SEA-URCHIN EMBRYOS TO AGENTS EVOKING CALCIUM SHOCK, General pharmacology, 29(1), 1997, pp. 49-53
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
29
Issue
1
Year of publication
1997
Pages
49 - 53
Database
ISI
SICI code
0306-3623(1997)29:1<49:NA(AQR>2.0.ZU;2-U
Abstract
1. Some nicotinic antagonists (piperidine and quinuclidine derivatives and bis-quaternary compounds) protect early embryos of the sea urchin Lytechinus pictus against a calcium shock evoked by ionomycin or a mi xture of phorbol myristate acetate and nicotine. 2. Maximal protective potency was found for drugs that did not penetrate the plasma membran e. 3. Early sea urchin embryos have nicotinic acetylcholine receptors (nAChR) or nAChR-like structures localized on the cell surface that, a pparently, take part in the control of Ca2+ influx. (C) 1997 Elsevier Science Inc.