Gg. Vaday et O. Lider, Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation, J LEUK BIOL, 67(2), 2000, pp. 149-159
Tissue injury caused by infection or physical damage evokes inflammatory re
actions and events that are necessary for regaining homeostasis, Central to
these events is the translocation of leukocytes, including monocytes, neut
rophils, and T lymphocytes, front the vascular system, through endothelium,
and into the extracellular matrix (ECM) surrounding the injured tissue, Th
is transition front the vasculature into the site of inflammation elicits r
emarkable changes in leukocyte behavior as cells adhere to and migrate acro
ss ECM before carrying out their effector functions. Growing evidence sugge
sts that, through its interactions with cytokines and degradative enzymes,
the ECM microenvironment has a specialized role in providing intrinsic sign
als for coordinating leukocyte actions. Recent advances also reveal that en
zymatic modifications to ECM moieties and cytokines induce distinctive cell
ular responses, and are likely part of the mechanism regulating the perpetu
ation or arrest of inflammation. This article reviews the findings that hav
e elucidated the dynamic relationships among these factors and how they com
municate with immune cells during inflammation.