ISOLATION OF BIOACTIVE COMPOUNDS FROM HELIX-ASPERSA NERVE-TISSUE AND THE EFFECT OF PQPPLPRYAMIDE ON HEART, ESOPHAGUS AND CENTRAL NEURONS OFHELIX-ASPERSA AND RECTUM OF ANODONTA-WOODIANA

Authors
OHTANI M MUNEOKA Y MATSUSHIMA O TAKAO T SHIMONISHI Y WHITE AR PEDDER S SHARMA R LENNON MA KATUGAMPOLA S WALKER RJ
Citation
M. Ohtani et al., ISOLATION OF BIOACTIVE COMPOUNDS FROM HELIX-ASPERSA NERVE-TISSUE AND THE EFFECT OF PQPPLPRYAMIDE ON HEART, ESOPHAGUS AND CENTRAL NEURONS OFHELIX-ASPERSA AND RECTUM OF ANODONTA-WOODIANA, General pharmacology, 29(1), 1997, pp. 103-111
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
29
Issue
1
Year of publication
1997
Pages
103 - 111
Database
ISI
SICI code
0306-3623(1997)29:1<103:IOBCFH>2.0.ZU;2-T
Abstract
1. Both acetone and methanol extraction was used to isolate bioactive compounds from 1000 Helix aspersa brains. 2. Seven compounds were isol ated of which four were identified as follows: Ha-1, 5-hydroxytryptami ne; Ha-3, GSPYFVamide; Ha-4, pQPPLPRYamide; Ha-5, SGYLAFPRMamide. Ther e was insufficient material to identify Ha-2, Ha-6 and Ha-7. 3. Ha-4, pQPPLPRYamide, was found to excite the heart of H. aspersa, relax the esophagus and both excite (mainly) and inhibit central neurons. In add ition, this peptide contracted the rectum of Anodonta woodiana, 4. It is concluded that pQPPLPRYamide is an example of a new molluscan pepti de family, designated as PRYamide. (C) 1997 Elsevier Science Inc.