Static versus dynamic distensibility of the carotid artery in humans

In clinical studies, the elastic behavior of central arteries is usually as sessed by measuring dynamic distensibility. In this study, we aimed to inve stigate how dynamic and static distensibility of the common carotid artery (D-dyn and D-stat, respectively) are related in 28 healthy volunteers of 20 -71 years. The carotid diameter and its change with the pressure pulse were measured using an ultrasound echo-tracking device. Arterial blood pressure was measured by Finapres and carotid pressure was determined by applanatio n tonometry. D-dyn was determined at rest using the pressure pulse, while D -stat was determined during presser responses induced by handgrip or cold p resser test. Data are given as mean +/- 1 SD. In younger subjects (<35 year s), D-stat did not differ from D-dyn (7.0 +/- 3.4 vs. 6.5 +/- 2.1.10(-3).mm Hg-1, respectively), whereas in older subjects (>35 years), D-stat was sig nificantly higher than D-dyn (3.8 +/- 1.4 vs. 2.1 +/- 0.9.10(-3).mm Hg-1, p <0.001). For all subjects, D-stat and D-dyn decreased with increasing age a nd mean arterial pressure (MAP). Using stepwise multiple regression analysi s, the strongest predictor of D-stat proved to be MAP, while that of D-dyn was age. D-stat was found to be linearly related to the hysteresis loop are a of the pressure-diameter relation (r = 0.94), i.e. to vessel wall viscosi ty. It is concluded that, with increasing age, static distensibility overes timates the distension capacity of large arteries. Copyright (C) 2000 S. Ka rger AG, Basel.