The aim of this study was to characterize the effects of brain natriuretic
peptide (BNP) on the hypothalamo-pituitary-adrenal (HPA) responses to diffe
rent stress paradigms (ether stress, electric shock and restraint). Rats we
re subjected to the stressful stimuli after intracerebroventricular adminis
tration of BNP (32.5 ng - 6.5 mu g) and plasma corticosterone was used as a
n indicator of the HPA activation. BNP did not modify the basal secretion,
but inhibited the stress-induced rise in plasma corticosterone in a dose-de
pendent manner. BNP proved most effective in decreasing the corticosterone
response to ether stress and attenuated the electric shock and restraint-in
duced HPA activation to a lesser extent. These results confirm the view tha
t BNP takes part in the regulation of the HPA system.