Detection of ventricular enlargement in patients at the earliest clinical stage of MS

The aim of this study was to determine whether atrophy could be detected at the earliest clinical stages of MS. Patients were selected from a 1-year f ollow-up MRI study of clinically isolated syndromes. Nine patients who deve loped MS were compared with eight matched patients who had no further sympt oms. Significant ventricular enlargement occurred in the group that develop ed MS but not in the other group. Our findings show that atrophy, albeit mi ld, can be detected early in the course of MS.