Objective: To compare the incidence of repeat pregnancy and method continua
tion rate at 12 months postpartum in young women who chose either depot med
roxyprogesterone acetate or oral contraceptives (OCs) as contraception.
Methods: We conducted a prospective cohort study of 122 postpartum women yo
unger than 18 years of age who delivered between January 8, 1997 and Decemb
er 31, 1997. patients choosing depot medroxyprogesterone acetate (n = 76) a
nd OCs (n = 46) were accrued for 12 months and were followed-up for a minim
um of 12 months. Main outcome measures were median contraceptive method con
tinuation and the incidence of repeat pregnancy at 12 months postpartum.
Results: There was no difference in mean age at delivery (P = .47), parity
(P = .84), or gravidity (P = .78) between depot medroxyprogesterone acetate
and OC users. At 12 months postpartum, 27.4% of OC users and 55.3% of depo
t medroxyprogesterone acetate users were still using contraception. Median
time to contraceptive discontinuation was longer for those choosing depot m
edroxyprogesterone acetate compared with OCs (17.8 vs 7.4 months, respectiv
ely, P = .002). The overall incidence of repeat pregnancy at 12 months post
partum was 10.6%. Among OC and depot medroxyprogesterone acetate users, res
pectively, 24% and 2.6% became pregnant again, producing a relative risk (R
R) of 9.09 (95% confidence interval [CI] 2.1, 39.2) for repeat pregnancy am
ong OC users. The mean time to repeat pregnancy (this was reported instead
of the median time whenever the pregnancy rate had not reached 50% at the e
nd of the follow-up period) was longer for depot medroxyprogesterone acetat
e compared with OC users (17.1 months vs 13.2 months, respectively, P < .00
1).
Conclusion: Adolescent mothers using depot medroxyprogesterone acetate inje
ction for contraception have a higher method continuation rate and a lower
incidence of repeat pregnancy at 12 months postpartum than those selecting
OCs during the same period. (C) 2000 by The American College of Obstetricia
ns and Gynecologists.