Intravitreal trovafloxacin against experimental Staphylococcus epidermidisendophthalmitis

This study was designed to test the effects of intravitreal trovafloxacin o n an experimental rabbit model of Staphylococcus epidermidis endophthalmiti s, Out of 26 rabbits, 22 were given intravitreal S, epidermidis (100,000 CF U). At 24 h, group 1 (8 rabbits) and, at 48 h, group 2 (8 rabbits) received 100 mu g intravitreal trovafloxacin. Group 3 (6 rabbits) was used as inocu lated but untreated controls. Four rabbits (group 4) were used as uninfecte d controls. Clinical scores were calculated at 24, 48 and 72 h. Microbiolog ical and histopathological scorings were made. Microbiological analysis sho wed that trovafloxacin administered at 24 or 48 h significantly reduced the number of bacteria compared to the untreated group, We conclude that trova floxacin applied at 24 or 48 h is effective against S, epidermidis endophth almitis in this experimental rabbit model. Copyright (C) 2000 S. Karger AG, Basel.