Citation
M. Carenza et al., Poly (acryloyl-L-proline methyl ester) hydrogels obtained by radiation polymerization for the controlled release of drugs, RADIAT PH C, 57(3-6), 2000, pp. 471-475
Citations number
13
Categorie Soggetti
Physics
Journal title
RADIATION PHYSICS AND CHEMISTRY
ISSN journal
0969806X
→ ACNP
Volume
57
Issue
3-6
Year of publication
2000
Pages
471 - 475
Database
ISI
SICI code
0969-806X(200003)57:3-6<471:P(MEHO>2.0.ZU;2-N
Abstract
Thermosensitive hydrogels were obtained by radiation-induced polymerization
of acryloyl-L-proline methyl ester in the presence of a crosslinking agent
. The measurements of equilibrium water content in the temperature range be
tween 0 degrees and 60 degrees C showed that the samples swelled at low tem
peratures while they shrank at high temperatures. These hydrogels were used
as drug delivery systems for the controlled release of insulin. In vivo st
udies carried out on diabetic rats ascertained a significant reduction in t
he hyperglycemic level in the blood which continued for about 2 months. (C)
2000 Elsevier Science Ltd. All rights reserved.