THE PURPOSE OF incorporating stereotactic methodology into neurosurgic
al operations is to achieve a consistently high degree of accuracy in
localizing intracranial targets. Therefore, the limits of resolution f
or the operation are a function of the accuracy of the particular ster
eotactic frame system. The total clinically relevant error (applicatio
n accuracy) comprises errors associated with each procedural step, inc
luding imaging, target selection, vector calculations, and the mechani
cal errors of stereotactic frames. To evaluate these parameters, a sys
tematic error analysis was carried out with four commonly used stereot
actic devices: the Brown-Roberts-Wells, the Cosman-Roberts-Wells, the
Kelly-Goerss COMPASS (modified Todd-Wells), and the Leksell frames. Ov
er 21,500 independent accuracy test measurements were made with 11,000
computed tomograms. The results suggest a potentially significant deg
ree of error in the application accuracy of all stereotactic instrumen
ts, which is accentuated by but not entirely due to imaging-associated
errors. Clinically encountered levels of weightbearing by stereotacti
c frames may have a pronounced effect on their mechanical accuracy. Bo
th the reapplication of aiming are assemblies and the use of phantom b
ase units introduce independent sources of mechanical inaccuracy into
stereotactic procedures. The scope of individual error values and thei
r determining factors must be considered with every clinical use of st
ereotactic frame systems.