Nonsequence-specific DNA recognition: a structural perspective

Authors
Murphy, FV Churchill, MEA
Citation
Fv. Murphy et Mea. Churchill, Nonsequence-specific DNA recognition: a structural perspective, STRUCT F D, 8(4), 2000, pp. R83-R89
Citations number
39
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE WITH FOLDING & DESIGN
ISSN journal
09692126 → ACNP
Volume
8
Issue
4
Year of publication
2000
Pages
R83 - R89
Database
ISI
SICI code
0969-2126(20000415)8:4<R83:NDRASP>2.0.ZU;2-X
Abstract
Chromosomal proteins that form essential architectural components of chroma tin bind and bend DNA with an intrinsic low degree of sequence preference. Comparisons made between two recently determined structures of high mobilit y group (HMG) protein-DNA complexes and other nonsequence-specific protein- DNA complexes reveal the structural basis of this important mode of DNA bin ding.