Synthesis of tetrahydro-beta-carbolines and studies of the Pictet-Spenglerreaction

Authors
Ducrot, P Rabhi, C Thal, C
Citation
P. Ducrot et al., Synthesis of tetrahydro-beta-carbolines and studies of the Pictet-Spenglerreaction, TETRAHEDRON, 56(17), 2000, pp. 2683-2692
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
17
Year of publication
2000
Pages
2683 - 2692
Database
ISI
SICI code
0040-4020(20000421)56:17<2683:SOTASO>2.0.ZU;2-E
Abstract
Tetrahydro-beta-carbolines have been prepared in a diastereomerically pure form by a short, efficient synthetic sequence consisting of reaction of cl- aminoaldehydes with tryptamine. A study was made of the major factors affec ting the stereoselectivity of the Pictet-Spengler reaction. (C) 2000 Elsevi er Science Ltd. All rights reserved.