Total synthesis of a sialylated and sulfated oligosaccharide from O-linkedglycoproteins

Authors
Xia, J Piskorz, CF Alderfer, JL Locke, RD Matta, KL
Citation
J. Xia et al., Total synthesis of a sialylated and sulfated oligosaccharide from O-linkedglycoproteins, TETRAHEDR L, 41(16), 2000, pp. 2773-2776
Citations number
31
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2773 - 2776
Database
ISI
SICI code
0040-4039(20000415)41:16<2773:TSOASA>2.0.ZU;2-1
Abstract
The total synthesis of a sialylated and sulfated oligosaccharide 1 represen tative of a structure occurring in respiratory mucins has been accomplished . Our strategy depends upon the employment of 2-naphthymethyl (NAP) protect ion for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for gly cosylation. (C) 2000 Elsevier Science Ltd. All rights reserved.