Direct displacement of -OH by nucleophiles in hydroxymethylimidazoles

Authors
Macor, JE Cornelius, LAM Roberge, JY
Citation
Je. Macor et al., Direct displacement of -OH by nucleophiles in hydroxymethylimidazoles, TETRAHEDR L, 41(16), 2000, pp. 2777-2779
Citations number
4
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2777 - 2779
Database
ISI
SICI code
0040-4039(20000415)41:16<2777:DDO-BN>2.0.ZU;2-W
Abstract
Direct displacement of -OH from 4- and 5-hydroxymethylimidazoles is achieve d in good to excellent yields simply by heating a 4- or 5-hydroxymethylimid azole in the presence of an appropriate nucleophile in refluxing basic wate r. (C) 2000 Elsevier Science Ltd. All rights reserved.