An improved synthesis of hydroxymethyl bipyridines

Authors
Smith, AP Corbin, PS Fraser, CL
Citation
Ap. Smith et al., An improved synthesis of hydroxymethyl bipyridines, TETRAHEDR L, 41(16), 2000, pp. 2787-2789
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2787 - 2789
Database
ISI
SICI code
0040-4039(20000415)41:16<2787:AISOHB>2.0.ZU;2-5
Abstract
This account describes quick and efficient syntheses of 4,4' -bis(hydroxyme thyl)-2,2'-bipyridine and 4-hydroxymethyl-2,2'-bipyridine from 4,4'-dimethy l-2,2'-bipyridine and 4-methyl-2,2'-bipyridine, respectively, via (trimethy lsilyl)methyl-, bromomethyl-, and acetoxymethyl- intermediates. (C) 2000 El sevier Science Ltd. Ail rights reserved.