Solid-state and solution conformations of eleutherobin obtained from X-raydiffraction analysis and solution NOE data

Authors
Cinel, B Patrick, BO Roberge, M Andersen, RJ
Citation
B. Cinel et al., Solid-state and solution conformations of eleutherobin obtained from X-raydiffraction analysis and solution NOE data, TETRAHEDR L, 41(16), 2000, pp. 2811-2815
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2811 - 2815
Database
ISI
SICI code
0040-4039(20000415)41:16<2811:SASCOE>2.0.ZU;2-K
Abstract
Single crystal X-ray diffraction analysis has revealed the solid-state conf ormation of the microtubule-stabilizing diterpenoid eleutherobin (1). NOE d ata obtained for 1 in CDCl3 and DMSO-d(6) are consistent with solution conf ormations that are virtually identical to the solid state conformation. (C) 2000 Elsevier Science Ltd. All rights reserved.