Diastereoselective amination of vinylic sulfoximines: application to the asymmetric synthesis of functionalized beta-substituted and beta,beta-disubstituted beta-amino acids, and of gamma-amino alcohols

Authors
Gais, HJ Loo, R Das, P Raabe, G
Citation
Hj. Gais et al., Diastereoselective amination of vinylic sulfoximines: application to the asymmetric synthesis of functionalized beta-substituted and beta,beta-disubstituted beta-amino acids, and of gamma-amino alcohols, TETRAHEDR L, 41(16), 2000, pp. 2851-2854
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2851 - 2854
Database
ISI
SICI code
0040-4039(20000415)41:16<2851:DAOVSA>2.0.ZU;2-F
Abstract
An asymmetric synthesis of protected beta-substituted and beta,beta-disubst ituted beta-amino acids, which carry a hydroxyalkyl side chain, from sulfon imidoyl functionalized homoallylic alcohols is described. The method allows for an asymmetric synthesis of amino alcohols as well. (C) 2000 Elsevier S cience Ltd. All rights reserved.