Pyridazines. Part 22: Highly efficient synthesis of pharmacologically useful 4-cyano-6-phenyl-5-substituted-3(2H)-pyridazinones

Authors
Sotelo, E Pita, B Ravina, E
Citation
E. Sotelo et al., Pyridazines. Part 22: Highly efficient synthesis of pharmacologically useful 4-cyano-6-phenyl-5-substituted-3(2H)-pyridazinones, TETRAHEDR L, 41(16), 2000, pp. 2863-2866
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2863 - 2866
Database
ISI
SICI code
0040-4039(20000415)41:16<2863:PP2HES>2.0.ZU;2-E
Abstract
A cyano group was directly and efficiently attached at the 4-position of th e heterocyclic ring of 5-substituted-6-phenyl-3(2H)-pyridazinones using a p ractical and mild procedure. This direct cyanide addition offers a novel an d one-pot approach to the synthesis of pharmacologically useful 4,5-difunct ionalized-6-phenyl-3(2H)-pyridazinones. (C) 2000 Elsevier Science Ltd. All rights reserved.