Nickel-mediated amination chemistry. Part 2: Selective N-arylation or N,N '-diarylation of piperazine

Authors
Brenner, E Schneider, R Fort, Y
Citation
E. Brenner et al., Nickel-mediated amination chemistry. Part 2: Selective N-arylation or N,N '-diarylation of piperazine, TETRAHEDR L, 41(16), 2000, pp. 2881-2884
Citations number
35
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
16
Year of publication
2000
Pages
2881 - 2884
Database
ISI
SICI code
0040-4039(20000415)41:16<2881:NACP2S>2.0.ZU;2-Z
Abstract
The 2,2'-bipyridine liganded Ni catalyst has revealed a good selectivity in the mono arylation of piperazine starting from aryl chlorides allowing a s elective and efficient synthesis of N-arylpiperazines using stoichiometric amounts of reagents. The preparation of N,N'-diaryl substituted piperazines is also described. (C) 2000 Elsevier Science Ltd. All rights reserved.