Diastereoselective synthesis of 3-amino-1,2-diols by reductive alkylation of 2,3-dialkoxynitriles

Authors
Hutin, P Larcheveque, M
Citation
P. Hutin et M. Larcheveque, Diastereoselective synthesis of 3-amino-1,2-diols by reductive alkylation of 2,3-dialkoxynitriles, TETRAHEDR L, 41(14), 2000, pp. 2369-2372
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
14
Year of publication
2000
Pages
2369 - 2372
Database
ISI
SICI code
0040-4039(20000401)41:14<2369:DSO3BR>2.0.ZU;2-O
Abstract
The addition of Grignard reagents to acetonide protected syn 2,3-dihydroxyn itriles, followed by reduction of the resulting magnesioimines, affords all syn 1,3-disubstituted 3-amino-1,2-diols in high enantiomeric purities. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.