Preparation of 5-substituted 2-carboxyindoles on solid support

Authors
Tois, J Franzen, R Aitio, O Huikko, K Taskinen, J
Citation
J. Tois et al., Preparation of 5-substituted 2-carboxyindoles on solid support, TETRAHEDR L, 41(14), 2000, pp. 2443-2446
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
14
Year of publication
2000
Pages
2443 - 2446
Database
ISI
SICI code
0040-4039(20000401)41:14<2443:PO52OS>2.0.ZU;2-4
Abstract
The preparation of 5-substituted 2-carboxyindoles on solid support is repor ted. In the approach, the indole moiety is synthesized in solution phase, f ollowed by nitro-group reduction, reductive amination and alkylation on sol id support. The method provides a simple and convenient route for the prepa ration of 5-substituted 2-carboxyindoles with high purity and good yield. ( C) 2000 Elsevier Science Ltd. All rights reserved.