Platinum catalysed hydrolytic amidation of unactivated nitriles

Authors
Cobley, CJ van den Heuvel, M Abbadi, A de Vries, JG
Citation
Cj. Cobley et al., Platinum catalysed hydrolytic amidation of unactivated nitriles, TETRAHEDR L, 41(14), 2000, pp. 2467-2470
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
14
Year of publication
2000
Pages
2467 - 2470
Database
ISI
SICI code
0040-4039(20000401)41:14<2467:PCHAOU>2.0.ZU;2-P
Abstract
The platinum(II) complex, [(Me2PO .. H .. OPMe2)PtH(PMe2OH)], efficiently c atalyses the direct conversion of unactivated nitriles to N-substituted ami des with both primary and secondary amines. Possible mechanisms for this re action are discussed and evidence for initial amidine formation is reported . Isolated yields vary from 51-89%. (C) 2000 Elsevier Science Ltd. All righ ts reserved.