Synthesis and resolution of 2-methyl-Quinazolinap, a new atropisomeric phosphinamine ligand for asymmetric catalysis

Authors
Lacey, PM McDonnell, CM Guiry, PJ
Citation
Pm. Lacey et al., Synthesis and resolution of 2-methyl-Quinazolinap, a new atropisomeric phosphinamine ligand for asymmetric catalysis, TETRAHEDR L, 41(14), 2000, pp. 2475-2478
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
14
Year of publication
2000
Pages
2475 - 2478
Database
ISI
SICI code
0040-4039(20000401)41:14<2475:SARO2A>2.0.ZU;2-K
Abstract
The preparation in a five-step sequence of 2-methyl-Quinazolinap, a new atr opisomeric ligand for asymmetric catalysis, is described. Diastereomeric pa lladacycles derived from racemic ligand and (+)-di-mu-chlorobis[(R)-dimethy l(1-( 1-naphthyl)ethyl)aminato-C-2,N]dipalladium(II) were separated by frac tional crystallisation. Displacement of the resolving agent by reaction wit h DPPE afforded enantiopure 2-methyl-Quinazolinap. (C) 2000 Elsevier Scienc e Ltd. All rights reserved.