Use of polymer supported thiophenol for the synthesis and purification of a benzimidazol-2-one library

Authors
Ermann, M Simkovsky, NM Roberts, SM Parry, DM Baxter, AD Montana, JG
Citation
M. Ermann et al., Use of polymer supported thiophenol for the synthesis and purification of a benzimidazol-2-one library, TETRAHEDR L, 41(14), 2000, pp. 2483-2485
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
14
Year of publication
2000
Pages
2483 - 2485
Database
ISI
SICI code
0040-4039(20000401)41:14<2483:UOPSTF>2.0.ZU;2-Y
Abstract
An efficient solution phase synthesis of substituted benzimidazol-2-ones is described. Polymer-supported thiophenol is used to remove excess alkylatin g agents. A library of 24 mono- and di-substituted benzimidazol-2-ones has been prepared in 60-99% yield and 65-99% purity. (C) 2000 Elsevier Science Ltd. All rights reserved.